FlexLab

Multi-step F-18 radiotracer production lab

The FlexLab is the most versatile F-18 radiosynthesizer specifically suited to the research, development and fully automated production of multi-step radiotracers.

 

The FlexLab allows the radiochemist to fully automate the radiosynthesis of multi-step compounds thereby improving synthesis yields, simplifying daily production and most importantly reducing the operators radiation exposure by completely eliminating the need of preform any manual processes.

For complex multi step F-18 radiotracer research & development, the FlexLab has been invaluable

 

Dr. Uwe Ackermann

Chief Research Radiochemist

Austin Hospital, Australia

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Open Up New Possibilities

The FlexLab is the only radiosynthesizer that is able to fully automate all the following synthesis steps:

Step 1:

18F Trapping onto QMA

Step 2:

Reactor 1:

Primary Reaction

Step 3:

SPE Purification of Primary Reaction Mixture

Step 4:

HPLC Purification of Primary Reaction Mixture

Step 5:

SPE Reformulation of Primary HPLC product

Step 6:

Reactor 2:

Secondary Reaction

Step 7:

SPE Purification of Secondary Reaction Mixture

Step 8:

HPLC Purification of Secondary Reaction Mixture

Step 9:

SPE Reformulation of Secondary HPLC product

Step 10:

Final Injectable Radiotracer

HPLC Without Limitations

The FlexLab's HPLC system has been designed to give radiochemist's all the tools they need to purify complex compounds multi-step compounds without any compromises.

FlexLab close-up

Dual HPLC Injectors

Allows two independent HPLC purifications in the one synthesis using independent HPLC loops & HPLC columns.

Dual HPLC Column Selector

Automatically select between two different HPLC columns and also provide a column by-pass.

Dual HPLC Product SPE Reformulation

Perform two independent S.P.E. purification of the collected HPLC product (one per HPLC system).

4 x HPLC Eluents

Automatic selection between the 4 eluents.

 

Fibre Optic UV/VIS Detector

Variable wavelength with a remote fibre optic flow cell.

 

Quaternary Low Pressure Gradient HPLC Pump

50mL/min pump head, quad channel degasser and mixer built-in.

 

HPLC device images: KNAUER Wissenschaftliche Geräte GmbH

Fibre Optic UV Flow Cell

Only the remote fibre optic flow cell is mounted inside the hotcell which frees up valuable space compared to a standard UV detector.

HPLC Low Pressure Gradients

Easily perform fully automated quaternary L.P.G. solvent elutions during your radiosynthesis.  All parameters are defined in your recipe file.

Eliminate Manual Solvent Mixing

Quaternary L.P.G. eliminates the need for manual mixing of your HPLC eluent - It's all done on-line.

Flexible Reactors

Easily swap between the standard 20mL reactor and the small volume 2mL reactor.

Open up new possibilities with the quick change small volume reactors by simplifying the transition to peptide labelling.

LN2 Main Reactor Cooling

Extend the cooling range of both main reactors to -80°C by combining it with our LN2 cooling option.

Quad Reactors

Add unparalleled quad reactor capabilities to the FlexLab.  The quad reactor option adds heating/cooling, radioactivity monitoring and magnetic stirrer bar mixing to both intermediate vials.

Small volume 2mL reactor

Standard 20mL reactor

Reactors available in either standard borosilicate glass or high purity  glassy carbon. Heating to 220°C & vortex tube compressed air cooling to ≈ 8°C.

Compact Dimensions

Install the FlexLab into virtually any hotcell.

Width 494mm  x  Height 466mm  x  Depth 416mm

Reduce your labs hotcell costs!

No longer do you need a large and expensive research hotcell to house all the equipment needed for complex multi-step synthesis.

The FlexLab easily fits into compact hotcell's with internal dimensions as small as 72cm x 60cm x 60cm (WxHxD) which can substantially reduce your laboratories costs.

Sensors

Complete & precise monitoring.

Radioactivity Detectors

Monitor every step of the synthesis with 10 collimated radioactivity detectors.

CsI(TI) crystal PIN photodiodes provide a linear response across a large radioactivity range.

HPLC Injection Fluid Detectors

Product injection into the HPLC loop's is controlled by two software calibrated optical fluid detectors.

  They allow on the fly adjustment of the detection threshold so that you never miss your product injection.

x10

Open User Interface

System control & visual synthesis recipe development all in one platform.

C-11 Pro2 software interface

The user interface combines both powerful features, yet easy to use tools for both daily operation and synthesis recipe development.

Easy to use open software interface for easy tracer development

Guides you step-by-step during the synthesis

Can be installed on multiple computers for remote synthesis

Recording of all process variables and report generation (21 CFR Part 11 & GMP compliant)

Traditional PC or Touch Screen Tablet Control

Built-in remote diagnostics enabling simplified troubleshooting

Synthesis Reports

Generate and print synthesis reports to satisfy you labs documentation and GMP requirements

Real-Time Sensors Trends

All sensor information can be displayed graphically in real-time trends

Historical Data Review

Review previous synthesis results as trend graphs with data analysis function

Graphical Synthesis Recipe Development

Click • Define • Save

SAVE STEP

1. Click Schematic

Click schematic elements such as valves, magnetic stirrers & vacuum pump to turn them on/off.

2. Define parameter

Define parameters such as reactor temperatures, HPLC pump parameters (flow rate & eluent composition) & step parameters (description, time, condition).

3. Save Step

Click the Save Step button and the software will automatically fill-in the Excel recipe step list automatically.

Synthesis recipes are stored as easily editable Excel step list files

Feature Comparison

Lets see how the FlexLab compares to other research synthesizers.

FEATURES

Other F-18 Synthesizers

Dual Reactors

Quad Reactors

LN2 Reactor Cooling

Dual Independent HPLC Purification

Quaternary LPG Pump + Degasser

Variable Wavelength Fibre

Optic UV/VIS Detector

Visual Synthesis Recipe Development

Dual SPE HPLC Product Reformulation

*
* *

* Optional Feature

Example of Compounds that have been Synthesized on the FlexLab

Radiotracer

Imaging

Yield @ E.O.S

(not corrected)

18F-FLT

Proliferation

10%

18F-FLETT (synthon: 18F-FEA)

Proliferation

40%

18F-FMISO

Hypoxia

30%

18F-NaphtoQuinone (synthon:18F-FB)

Hypoxia

10%

18F-FES

Estrogen

20%

18F-MEL50/54

Melanoma

18F-FDHT

Tumor (androgen receptor expression)

20%

18F-FPPRGD2 (synthon: 18F-NFP)

Peptide (αv & β3 integrin expression)

10%

18F-GalactoRGD (synthon: 18F-NFP)

Peptide (αv & β3 integrin expression)

10%

18F-PBR111

Peripheral Benzodiazepine Receptor

30%

1

1

1

1

1

1

3

3

4

2

Synthon

 

18F-SFB

 

18F-

FBEM

25%

Coupling to amine

1 Ackermann, U., Austin Hospital

2 Australian Nuclear Science & Technology Organisation, Lucas Heights

3 Roselt, P., Peter MacCallum Cancer Centre

4 Bourdier, T., Royal Prince Alfred Hospital

Radiochemical yield not decay corrected

18F-FEA

18F-FP

18F-NFP

18F-FB

18F-FBA

18F-DBCO

Coupling to free amine of single chain antibody

Peptide (Cu catalysed click chemistry)

Peptide

Neovascularisation: coupling to peptide

Coupling to hydroxymethyl napthoquinone

Coupling to sulfhydryl group of modified single chain antibody

Peptide: Cu-free click chemistry

Chemistry

25%

90%

20%

20%

35%

40%

10%

Yield @ E.O.S

(not corrected)

N-Succinimidyl 4-[18F]Fluorobenzoate

2-[18F]Fluoroethylazide

2-[18F]Fluoropropionic acid

4-nitrophenyl 2-[18F]fluoropropionate

[18F]Fluorobenzoic acid

N-[2-(4[18F]Flurobenzamido)Ethyl]
malemide

4-[18F]Fluorobenzaldehyde

[18F]-Dibenzocyclooctyne (free amine on chain)

FlexLab Users

Some of the institutions that are using the FlexLab.

iPHASE Support?

Key aspects of our support structure

Spare Parts

Complete stock of spare parts for all synthesizers are available and can be expressed shipped to you to minimise downtime.

Continuing Education

The field of radiochemistry is

ever changing and our education program is there to ensure your team is fully up to date with our latest developments.

Technical Support

You are always  a phone call or an email away from an experienced iPHASE engineer or staff member to assist with any queries.  Achieving customer satisfaction is our primary objective.

Upgrades

Due to the ever evolving nature of technology, we are continually  following the trends and applying the latest technologies to our systems to increase performance, productivity and reliability.

Remote diagnostics

Remote diagnostics are built into every system we make. This enables our experienced engineers to diagnose, test and guide the user to the quickest solution to an issue should it arise.

Hands on Training

Personalized hands on training will ensure your staff will easily learn and master all aspects of our automated technology.

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